Jose Mourinho said he will recall Antonio Valencia, Nemanja Matic and Romelu Lukaku, who were all rested in midweek against Bournemouth.Phil Jones and Daley Blind both returned from injury in that game and may be involved at Wembley.
Dele Alli is among several expected Tottenham changes, having been left out for the midweek draw with Brighton.
Danny Rose remains sidelined by a calf issue and Harry Winks is a long-term absentee with an ankle problem.
The teams have met in 10 previous FA Cup ties, progressing five times each.Manchester United have won each of their last three FA Cup ties against Tottenham, in 1997, 2008 and 2009. Their most recent defeat came in a third-round replay in January 1980.
This will be Manchester United’s 29th appearance in the FA Cup semi-finals – equalling Arsenal’s record set last season.After a run of 13 straight FA Cup semi-final wins, the Red Devils have been eliminated from two of their last three – in 2009 against Everton and 2011 versus Manchester City.Romelu Lukaku has scored in every round Manchester United have played in so far this season, netting five goals in total.Alexis Sanchez has scored five goals in his four FA Cup games at Wembley Stadium, including the winner in both semi-final appearances.Jose Mourinho could become the third manager to win the FA Cup with two different clubs, after Herbert Chapman with Huddersfield Town in 1922 and Arsenal in 1930, and Billy Walker with Sheffield Wednesday in 1935 and Nottingham Forest in 1959.
Tottenham have lost each of their last seven FA Cup semi-final ties – the longest such run in the competition’s history.Spurs are the highest scorers in this season’s FA Cup, with 17 goals in six games.The last club to be knocked out of the FA Cup at the semi-final stage in consecutive seasons was Nottingham Forest in 1987-88 and 1988-89, with both defeats coming against Liverpool.Son Heung-min has had a hand in 14 goals in his 15 FA Cup appearances (nine goals, five assists) – more than any other player in the competition over the past three seasons.Erik Lamela has been directly involved in five goals in his last four FA Cup appearances (two goals, three assists).